Cardiac Physiology Mnemonics

By : Dr. Subrahmanyam Karuturi

> PGI2 vs. TxA2 coagulation function TxA2 Aggregates platelets.
PGI2 Inhibits aggregation.
· Note: full name of PGI2 is prostaglandin I2 or prostacyclin, full name of TxA2 is thromboxane A2.
 

> Heart: -tropic definitions Lusitropic: loose is relaxed. Definition: relax heart.
Inotropic: when heart wall contracts, moves inward. Definition: contract heart.
Chronotropic: 'chrono-' means 'time'. Defintion: heart rate (of SA node impulses).
Dromotropic: only one left, it must be conduction speed by default.

 
 
  > Intrinsic vs. extrinsic pathway tests "PeT PiTTbull":
PeT: PT is for extrinsic pathway.
PiTTbull: PTT is for intrinsic pathway.

 
  > Carotid sinus vs. carotid body function carotid SinuS: measures preSSure.
carotid bO2dy measures O2.

> Hemoglobin and myoglobin: binding strengths, sites "ABC" of glycosylated Hb (Hb1c):
· Glucose binds to Amino terminal of Beta Chain.
"HbF binds Forcefully":
· HbF binds oxygen more forcefully than HbA, so Oxy-Hb dissociation curve shifts to left.
Stored blood is SOS:
· Stored blood Hb binds to Oxygen Strongly because of decrease in 2,3 BPG.
2,3 BPG binding site is BBC:
· BPG binds to Beta Chain of Hb.
Myoglobin binding strength is MOM:
· Myoglobin binds Oxygen More strongly than Hb.
 

> Hb-oxygen dissociation curve shifts: effect, location Left shift: causes Loading of O2 in Lungs.
Right shift: causes Release of O2 from Hb.

> Fluid compartments: volumes 12345:
12 liters of interstitial fluid
3 liters plasma volume and 30 liters inside cells
45 liters total body water

> Adrenoceptors: vasomotor function of alpha vs. beta ABCD:
Alpha = Constrict.
Beta = Dilate.

> Coagulation common pathway: factors in order 10 + 5 - 2 = 13
Coagulation common pathway:
Factor X to Factor V to Factor II to Factor XIII

 
  > Vitamin K dependent cofactors "Several Tend To Nicely Stop Clots":
Factor Seven, Ten, Two, Nine.
Protein S, Protein C.

> ADP: role in platelet aggregation ADP

= Aggregation from the Dense bodies of Platelets.

> Protein C, Protein S: function C and S are:
Clot
Stoppers
· These proteins inhibit coagulation.

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